Mechanistic
Interventions.
We do not treat symptoms; we debug the code.We target the master regulators of cellular entropy.
Metabolic Integrity
Mitochondrial dysfunction drives cellular senescence. We focus on two axes: restoring NAD+ homeostasis and enforcing mitochondrial quality control.
CD38 Inhibition
CD38 is the primary 'NADase' that degrades NAD+ with age. Inhibiting it restores levels without needing precursors.
PINK1 / Parkin
The 'eat me' signal for damaged mitochondria. Enhancing this axis clears metabolic junk.
AMPK Activation
The master metabolic switch. Mimicking caloric restriction to induce biogenesis.
The Inflammasome
Inflammaging is not random; it is a specific, cascade-driven process. We block the assembly of the protein complexes that initiate the fire.
NLRP3 Assembly
Targeting the NEK7-NLRP3 interaction to prevent the oligomerization of the inflammasome structurally.
cGAS-STING
The sensor of cytosolic DNA (from nuclear rupture or mitochondrial leak). Blocking this prevents sterile inflammation.
Senolytics
Selectively inducing apoptosis in senescent cells that secrete SASP factors.
Proteostasis
Neurodegeneration is a failure of clearance. The brain drowns in its own waste (Beta-Amyloid, Tau). We must upregulate the garbage disposal systems.
TFEB Activation
Transcription Factor EB is the master regulator of lysosomal biogenesis. Nuclear translocation of TFEB increases clearance capacity.
Chaperone-Mediated Autophagy
Targeting LAMP2A to selectively drag toxic proteins into the lysosome.
UPR Modulation
Unfolded Protein Response. Tuning the ER stress response to prevent apoptosis.